Variante brasiliana Ciccozzi – L’intervista all’esperto Massimo Ciccozzi e le sue parole sulla variante brasiliana del Covid. Le ultime notizie sul coronavirus dal mondo e dall’Italia tutte le ultime news aggiornate in tempo reale.
Dopo la variante inglese e sudafricana, c’è una nuova mutazione del coronavirus Sars-Cov-2 a destare preoccupazione. Si tratta della variante brasiliana: diagnosticata a Manaus, in Brasile, e isolata l’11 gennaio scorso dall’Istituto nazionale giapponese per le malattie infettive (Niid).
“Quello che preoccupa maggiormente di questa variante è la sua sospetta capacità di sfuggire al sistema immunitario. Inoltre, il virus mutato sarebbe non solo più infettivo, ma potrebbe anche re-infettare chi è già stato colpito dal Covid-19”.
Lo racconta l’epidemiologo Massimo Ciccozzi, ordinario di statistica medica ed epidemiologica molecolare all’Università Campus Biomedico di Roma.
Variante brasiliana Ciccozzi, l’intervista all’esperto
Professore ci spiega quali sono le caratteristiche della variante brasiliana e quali invece le differenze con le altre già in circolazione?
“Partiamo intanto dal nome: quest’ultima è indicata con la sigla B.1.1.248 e nasce da 12 mutazioni concentrate sulla principale arma del virus, la proteina Spike. Nello specifico le varianti brasiliane sono in realtà due: una con tre mutazioni, la B.1.1.28 (K417N / E484K / N501Y), ribattezzata P.1, e l’altra con una sola mutazione, la B.1.1.28 (E484K). Si differenzia dalla altre anche per questo: la variante inglese ha 9 mutazioni concentrate nella Spike, quella sudafricana ne ha 8 e quella italiana (N501T) ne ha 5”.
Torniamo alle due varianti brasiliane. Cosa hanno invece di diverso l’una dall’altra?
“Secondo i primi studi, pare che la B.1.1.28 (E484K) eluda gli anticorpi, ovvero è come se questi ultimi funzionassero ma dieci volte volte meno, mettendoci più tempo a neutralizzarla. E questo puo essere un problema”.
Esistono, invece, analogie con qualche variante in particolare?
“Sono tutte varianti più o meno portate ad avere una maggiore contagiosità. Quella brasiliana e sudafricana però potrebbero far diminurie maggiormente la forza degli anticorpi neutralizzanti. Inoltre la brasiliana come la sudafricana ha la mutazione E484K, a differenza di quella inglese e italiana. Sono mutazioni che rendono le varianti diverse dal ceppo originario”.
La variante brasiliana mette a rischio l’efficacia dei vaccini?
“Al momento pare di no. Nessuna delle varianti in circolazione, ma non prevalenti rispetto al ceppo originario di Whuhan e successivamente soppiantato dal ceppo DG614, sembra mettere in pericolo l’efficacia dei vaccini. Dopo la prima variazione, la DG614, identificata tra febbraio e marzo negli Usa e in Europa, in estate sono inziate a comparire le altre: prima quella spagnola (20A), a seguire quella danese (Y453) che ha infettato i visoni, poi inglese, sudafricana, brasiliana/giapponese, italiana. Sei varianti nel giro di qualche mese significa solo una cosa: che il virus muta e anche velocemente a dispetto di chi diceva, all’inizio della pandemia, che il virus non mutava”.
Esclusa l’inefficacia del vaccino, cosa c’è da temere?
“Il vero problema è la sua circolazione. Il virus non deve circolare per due motivi: primo, perché più circola, più è probabile che una persona si possa re-infettare con questa variante; secondo, perché il virus, sotto pressione dei vaccini, è spinto a mutare e non sappiamo quali altre mutazioni possano avvenire. Quindi non escludo che potrebbero esserci in futuro altre varianti. Prevederle è impossibile”.
Come si potrebbe frenare la corsa del virus?
“Innanzitutto occorrerebbe creare un sistema di sorveglianza e monitaraggio molecolare, che ci aiuterebbe a capire quali sono le varianti e in che misura circolano nel nostro Paese. In Italia ancora manca. Secondo poi bisognerebbe accettare in maniera definitiva che l’idea paventata da alcuni studiosi di provare l’immunità di gregge facendo infettare le persone è fallita , sia perché il virus muta per natura sia perché sono molteplici i ceppi in circolazione”.
C’è qualche suo studio in itinere?
“Sì. Stiamo studiando insieme al professor Arnaldo Caruso l’effetto di una mutazione chiamata Q493K, molto vicina alla mutazione N501T, ovvero alla variante italiana che abbiamo già identificato nei giorni scorsi a Brescia. Vogliamo capire se ha un effetto neutralizzante o meno”.
Sabato scorso il ministro della salute Roberto Speranza ha firmato un’ordinanza per bloccare i voli in partenza dal Brasile e vietare l’ingresso nel nostro Paese di chi negli ultimi 14 giorni vi è transitato. Può bastare?
“No. Dobbiamo assolutamente monitorare non solo tutti i viaggi provenienti dal Brasile ma anche quelli provenienti da altri scali e che implicano comunque l’arrivo di passeggeri dal Brasile. Questo vale anche per chi giunge dall’Inghilterra”.
Quante probabilità ci sono che la variante brasiliana sia arrivata già in Italia?
“Ancora non si hanno dati su questo. Sappiamo che l’allarme è partito dal Giappone e che un caso è stato registrato anche in Gran Bretagna. Sono invece maggiori i dati sulla presenza della variante inglese: a Roma un caso, come nel bergamasco. Mentre nelle Marche 51 su 133 campioni sequenziati avevano la variante inglese”.
Fonte: Repubblica
Everything is very open with a clear explanation of the issues.
It was truly informative. Your website is very useful. Thank
you for sharing!
Here is my web page :: chemung canal login (http://www.creditcardapr.org)
Thank you for the good writeup. It in fact was a amusement account it.
Look advanced to far added agreeable from you! However,
how can we communicate?
I really like what you guys are usually up too. This sort of clever
work and exposure! Keep up the awesome works guys I’ve incorporated you
guys to blogroll.
You actually make it seem so easy with your presentation but I find
this matter to be actually something which I think I would
never understand. It seems too complicated and
very broad for me. I am looking forward for your next post, I will try to get
the hang of it!
Thank you for every one of your efforts on this web page.
Kate really likes making time for investigations and it’s
really easy to understand why. I know all concerning the lively mode you produce priceless tricks by means of
your website and therefore welcome response from other individuals on this
idea while my daughter is truly learning a lot. Take advantage of the rest of the new year.
You are always carrying out a powerful job.[X-N-E-W-L-I-N-S-P-I-N-X]I
am extremely inspired with your writing talents and also with the format for
your blog. Is this a paid subject matter or did you modify it yourself?
Either way keep up the excellent quality writing, it’s uncommon to look a nice
weblog like this one these days.
Very interesting info!Perfect just what I was searching for!
Yes! Finally something about atkins diet.
You actually make it seem so easy with your
presentation but I find this topic to be actually something which I think I would never understand.
It seems too complex and extremely broad for me.
I’m looking forward for your next post, I’ll try to get the hang of it!
We absolutely love your blog and find nearly all of
your post’s to be just what I’m looking for. can you offer
guest writers to write content for you? I wouldn’t
mind writing a post or elaborating on most of the subjects you write about
here. Again, awesome weblog!
As I website possessor I think the subject material
here is really excellent, thank you for your efforts.
Pretty section of content. I just stumbled upon your site
and in accession capital to assert that I acquire
in fact enjoyed account your blog posts. Any way I will be subscribing
to your augment and even I achievement you access consistently quickly.
Thank you for the sensible critique. Me & my neighbor were
just preparing to do a little research on this. We got a grab a book from our area library but I think I
learned more from this post. I’m very glad to see such
fantastic information being shared freely out there.
I have read so many posts on the topic of the blogger lovers however this piece of writing is
truly a nice article, keep it up.
This website was… how do I say it? Relevant!! Finally I have found something that helped me.
Thanks a lot!
I?m amazed, I must say. Seldom do I encounter a blog that?s
both educative and interesting, and let me tell you, you have hit the nail on the
head. The issue is something which not enough men and
women are speaking intelligently about. I am very happy that I found this during my
hunt for something concerning this.
I need to to thank you for this great read!! I absolutely loved every little bit of it.
I’ve got you book-marked to look at new things you post?
I have read so many posts regarding the blogger lovers however this post is genuinely a good piece of writing, keep it up.
I?m amazed, I have to admit. Seldom do I come across a blog that?s equally educative and
engaging, and without a doubt, you have hit the nail on the
head. The problem is something that not enough men and women are speaking intelligently about.
I am very happy I found this in my hunt for something concerning this.
I every time used to read piece of writing in news papers but now as I am a user of internet so from now I am using net for
articles or reviews, thanks to web.
Hi there, I want to subscribe for this webpage to obtain latest
updates, thus where can i do it please help out.
Its like you read my mind! You seem to know so much about this, like you wrote
the book in it or something. I think that you could do with a few pics to drive the message home a bit, but instead
of that, this is magnificent blog. An excellent read. I will certainly be back.
I’m impressed, I have to admit. Rarely do I come across a blog that’s both equally educative
and engaging, and without a doubt, you’ve hit the nail on the head.
The problem is something which not enough folks are speaking intelligently about.
I’m very happy that I came across this in my hunt for something regarding this.
Hi! I could have sworn I?ve been to this site before but after browsing through some of the posts I realized it?s new to me.
Anyways, I?m definitely delighted I stumbled upon it and I?ll
be bookmarking it and checking back often!
Thank you, I have just been looking for information approximately this subject
for a long time and yours is the greatest I’ve found out till now.
But, what concerning the conclusion? Are you positive concerning the supply?
Hello to every one, the contents existing at this web site
are really remarkable for people experience, well, keep up the good work fellows.
First off I would like to say superb blog! I had a quick question that I’d like to ask
if you do not mind. I was curious to find out how you center yourself
and clear your head prior to writing. I have had a difficult time clearing my mind in getting my thoughts out
there. I do take pleasure in writing however it just seems like the
first 10 to 15 minutes are lost just trying to figure out
how to begin. Any recommendations or hints? Thanks!
Oh my goodness! Impressive article dude! Thanks, However I
am going through problems with your RSS. I don’t understand why I can’t join it.
Is there anyone else having similar RSS issues?
Anybody who knows the solution can you kindly respond?
Thanks!!
Can you tell us more about this? I’d like to find out more
details.
I conceive this website holds some really wonderful information for everyone
:D.
Can you tell us more about this? I’d care to find out some additional information.
I just like the valuable information you supply in your articles.
I will bookmark your weblog and take a look at again right here
frequently. I’m quite certain I’ll be informed many new stuff right right here!
Best of luck for the following!
Thank you for every other magnificent article. The place else may anybody get that kind of information in such an ideal method of writing?
I have a presentation next week, and I’m on the look for such info.
Somebody necessarily lend a hand to make seriously articles
I might state. That is the first time I frequented your website
page and to this point? I amazed with the research you made to make this actual post extraordinary.
Excellent activity!
Visit my web site … cash offer please™
Excellent article. I definitely love this website.
Stick with it!
I’m гeally impressed along with yоur writing skills as neatly as with the ⅼayout in your blog.
Is thіs a pаid subject matter or did you modify it yourseⅼf?
Anyway keep up the excellent quality writіng, it’s rare to see a
grеat weblog like this one nowadays..
great publish, very informative. I wonder why the opposite specialists of this sector don’t notice
this. You must proceed your writing. I’m confident, you’ve a great readers’ base already!
I’ve recently started a blog, the information you provide on this web site has helped me tremendously. Thanks for all of your time & work.
We absolutely love your blog and find the majority of your post’s to be exactly what I’m looking for.
can you offer guest writers to write content for you personally?
I wouldn’t mind creating a post or elaborating on a number of the subjects you write related to here.
Again, awesome web log!
Definitely believe that which you said. Your favorite justification appeared to be on the internet the simplest thing to be aware of. I say to you, I certainly get annoyed while people think about worries that they plainly do not know about. You managed to hit the nail upon the top as well as defined out the whole thing without having side-effects , people can take a signal. Will likely be back to get more. Thanks
Hiya, I’m really glad I have found this information. Nowadays bloggers publish only about gossips and web and this is really frustrating. A good web site with exciting content, this is what I need. Thanks for keeping this website, I will be visiting it. Do you do newsletters? Cant find it.
Good info. Lucky me I reach on your website by accident, I bookmarked it.
This design is wicked! You certainly know how to keep a reader amused. Between your wit and your videos, I was almost moved to start my own blog (well, almost…HaHa!) Wonderful job. I really enjoyed what you had to say, and more than that, how you presented it. Too cool!
Really informative and great bodily structure of subject material, now that’s user genial (:.
Dead written articles, thankyou for selective information.
This is the right blog for anyone who wants to find out about this topic. You realize so much its almost hard to argue with you (not that I actually would want…HaHa). You definitely put a new spin on a topic thats been written about for years. Great stuff, just great!
There is clearly a bunch to know about this. I suppose you made certain good points in features also.
I got what you intend,saved to fav, very nice internet site.
The crux of your writing while appearing agreeable in the beginning, did not really sit well with me after some time. Someplace throughout the sentences you managed to make me a believer but just for a very short while. I nevertheless have a problem with your leaps in assumptions and you might do well to fill in those gaps. In the event you actually can accomplish that, I could surely be fascinated.
I’ve been exploring for a bit for any high-quality articles or blog posts on this sort of area . Exploring in Yahoo I at last stumbled upon this web site. Reading this info So i am happy to convey that I’ve a very good uncanny feeling I discovered just what I needed. I most certainly will make certain to do not forget this website and give it a look regularly.
Nice post. I learn something more challenging on different blogs everyday. It will always be stimulating to read content from other writers and practice a little something from their store. I’d prefer to use some with the content on my blog whether you don’t mind. Natually I’ll give you a link on your web blog. Thanks for sharing.