Crucifere – Le piante da cui è stato scoperto il composto naturale che riesce a bloccare il coronavirus: lo studio italiano. Le ultime notizie dall’Italia e dal mondo sul Covid tutte le ultime news aggiornate in tempo reale ogni giorno 24 ore su 24.
Un composto naturale prodotto dalle piante Crucifere (Brassicaceae). Questo sarebbe in grado di “intrappolare” il coronavirus SARS-CoV-2 all’interno delle cellule, ostacolando la replicazione e impedendo la diffusione nel resto dell’organismo. In parole semplici, grazie a questo vero e proprio blocco – che colpisce gli enzimi responsabili della fuoriuscita virale, un meccanismo biologico chiamato “cell egression” – è possibile arrestare l’infezione. E neutralizzare il patogeno.
I risultati sono stati ottenuti in laboratorio su cellule coltivate in provetta (test in vitro). Tuttavia, poiché il composto naturale coinvolto è sicuro e viene già utilizzato per il trattamento di altre condizioni mediche, come la papillomatosi respiratoria ricorrente, gli autori della scoperta sono fiduciosi sul fatto che possa passare rapidamente alla fase clinica. Anche per poterne dimostrare le spiccate capacità antivirali anche nell’uomo.
La sostanza in grado di bloccare il coronavirus nelle cellule è l’indolo-3-carbinolo (I3C), che derivata dalla degradazione di composti glucosidici presenti nella maggior parte delle piante Crucifere. Come cavoli, broccoli, cavolfiori, cavoletti di Bruxelles e simili.
Crucifere, le piante che hanno portato alla scoperta italiana contro il Covid
A scoprire le sue proprietà contro il patogeno pandemico è stato un team di ricerca internazionale guidato da scienziati italiani dell’Università di Tor Vergata, dell’Università di Torino e dell’Università del Nevada (Stati Uniti). Questi hanno collaborato a stretto contatto con i colleghi del Beth Israel Deaconess Cancer Center della Scuola di Medicina dell’Università di Harvard; del Dipartimento di Epidemiologia e Ricerca Preclinica dell’Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani (INMI) di Roma; del Laboratorio di Genetica Medica dell’IRCCS Ospedale Pediatrico Bambino Gesù; dell’Università di Boston e di numerosi altri istituti.
Hanno partecipato all’indagine anche alcuni consorzi di ricerca, come il COVID Human Genetic Effort, il French COVID Cohort Study Group e il CoV-Contact Cohort.
Gli scienziati, coordinati dai professori Giuseppe Novelli del Dipartimento di Biomedicina e Prevenzione dell’ateneo romano e Pier Paolo Pandolfi del Dipartimento di Biotecnologie Molecolari e Scienze della Salute dell’ateneo di Torino (oltre che docente in due istituti americani), sono giunti alle loro conclusioni dopo aver scoperto la classe di enzimi umani che il coronavirus SARS-CoV-2 sfrutta per uscire dalle cellule infettate e diffondersi nel resto dell’organismo, determinando la COVID-19 (la patologia).
Si chiamano E3-ubiquitin ligasi (HECT-E3) e sono coinvolti nella fase di “cell egression” di virus a RNA come il mortale Ebola, “attraverso l’interazione diretta della sua proteina VP40”, si legge nell’abstract dello studio. Due di questi enzimi, chiamati NEDD4 e WWP1, interagiscono con la proteina S o Spike del coronavirus, e come specificato permetto la diffusione virale.
Le parole degli scienziati italiani
Gli scienziati hanno scoperto che questi enzimi risultano essere sovraespressi nei pazienti colpiti dalla forma grave della COVID-19, così come in modelli murini (topi) geneticamente modificati e infettati dal SARS-CoV-2.
Nei test in vitro l’indolo-3-carbinolo (I3C), che è un inibitore naturale di NEDD4 e WWP1, ha mostrato “potenti effetti antivirali e inibisce la fuoriuscita virale”. Grazie alle basi gettate da questo studio sarà possibile mettere a punto farmaci costruiti attorno al principio attivo che puntano a bloccare la replicazione del virus e ad arrestarne la trasmissione. Potenzialmente potranno essere utilizzati anche in combinazione con altre terapie.
“Un vaccino è solo una misura profilattica. Dobbiamo testare il farmaco in studi clinici con pazienti Covid-19 per valutare rigorosamente se può prevenire la manifestazione di sintomi gravi e potenzialmente fatali. Avere opzioni per il trattamento, in particolare per i pazienti che non possono essere vaccinati, è di fondamentale importanza per salvare sempre più vite umane e contribuire ad una migliore condizione e gestione della salute pubblica”. Questo ha dichiarato il professor Novelli.
“Dobbiamo pensare a lungo termine. I vaccini, pur essendo molto efficaci, potrebbero non esserlo più in futuro, perché il virus muta. E quindi è necessario disporre di più armi per combatterlo. La scoperta su I3C è importante, e ora dobbiamo avviare studi clinici per dimostrare la sua potenziale efficacia”. Questo ha affermato il professor Pandolfi. Aggiungendo che sarà importante anche capire se il farmaco sarà efficace contro la cosiddetta “Long COVID”. I postumi dopo aver superato la fase acuta, che possono durare per mesi.
I dettagli della ricerca “Inhibition of HECT E3 ligases as potential therapy for COVID-19” sono stati pubblicati. Sono, infatti, disponibili sull’autorevole rivista scientifica specializzata Cell Death & Disease del circuito Nature.
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Weisz: The issues of different state and local laws is simply a matter of politics. Again, there is an important distinction between medical and recreational use, as some of the “red” states do allow for medical use, again with different requirements. Different states and localities have laws reflecting their constituencies. Even in California, some cities allow dispensaries and others do not. On a federal level, for similar reasons, I do not see legalization in the near future. It seems much likely that cannabis will remain a state issue for the foreseeable future. Some of the political resistance is easing. Congress passed its first stand-alone marijuana reform bill last week, which will allow for more research into medical uses if Biden signs it into law, as expected. Several state legislatures, including Vermont’s and Virginia’s, have legalized marijuana for recreational purposes. Some prominent Democrats, like Senator Bernie Sanders and the Senate majority leader, Chuck Schumer, have voiced support for legalization.
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Cannabis NB is the only legal retailer of cannabis. Canada also does something no state has done, namely allowing bans on risky, high potency products, such as certain edibles and concentrates. These products, which have levels of THC (the principal intoxicant in cannabis) many times that of traditional smoked flower cannabis, present risks that scientists only partially understand, but which are probably most significant for adolescents because of the neuroplasticity of their brains. As a result, employers will be urged to implement policies on drug use, in particular to meet their health and safety obligations and to prevent any risk of accident. However, these policies will have to take into consideration the state of the law regarding drug testing. To date, random drug testing is forbidden in Canada except in very specific circumstances.
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