Variante Milano Covid – Una nuova variante del virus Sars-cov-2 è stata scoperta dai virologi della Statale di Milano. La mutazione non coinvolge la proteina Spike del virus e quindi non sembra modificare la sua capacità di infettare ma è comunque di grande interesse, perché potrebbe influire sulla risposta immunitaria contro il virus da parte dell’organismo umano.
La mutazione, il cui sequenziamento è stato pubblicato sulla rivista Emerging Microbes & Infections e la cui scoperta è avvenuta in seguito all’analisi dei campioni virali raccolti da due medici ammalatisi di Covid-19 lo scorso marzo a Milano, riguarda una proteina chiamata ORF-6.
Variante Milano Covid, ecco cosa sta succedendo
“La nuova mutazione è presente nel gene virale che codifica per la proteina accessoria ORF-6 e porta alla produzione di ORF-6 troncata, mancante di 6 aminoacidi”, spiega il virologo Pasquale Ferrante dell’Università degli Studi di Milano e direttore della struttura Istituto Clinico Città Studi, coordinatore del lavoro insieme a Serena Delbue e a Elena Pariani, responsabile del centro di riferimento regionale di sorveglianza dei virus influenzali.
Con le sue 30mila basi, il genoma di Sars-Cov-2 è enorme rispetto agli altri virus: l’Hiv è di 9mila basi e quello dell’epatite C di 10mila. Al momento, la ricerca si concentra sull’area del genoma che contiene le sequenze per la produzione delle proteine di superficie, come la glicoproteina Spike, “perché siamo interessati alla genesi degli anticorpi protettivi e alla loro capacità di azione anche di fronte alle mutazioni virali – spiega il professore – ma c’è un’altra regione del genoma virale che contiene i geni dalle funzioni accessorie e lì si trova la nuova mutazione che abbiamo scoperto”.
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